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In patients with cirrhosis, the main risk factors for developing overt HE include MHE, sarcopenia, hyponatremia, epilepsy, type 2 diabetes, elevated creatinine, elevated bilirubin, and hypoalbuminemia.1 Because overt HE is a manifestation of decompensated liver failure, it has a negative impact on survival

Some markets that I think lend themselves to this dynamic are drugs for addiction, innovations in organ transplantation, drug + device combinations, psychedelic therapies, sarcopenia, frailty, or drugs for aging that appears to be a growing category

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It is also possible that radical intermediates nonenzymatically produced from hydroperoxy-phospholipids directly react with GSH, leading to the formation of a highly pro-oxidant GS radical